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KMID : 1094020180350060258
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Journal of Veterinary Clinics
2018 Volume.35 No. 6 p.258 ~ p.265
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Associations of Puerperal Metritis with Serum Metabolites, Uterine Health, Milk Yield, and Reproductive Performance in Dairy Cows
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Jeong Jae-Kwan
Kang Hyun-Gu
Kim Ill-Hwa
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Abstract
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We aimed to identify the relationships between puerperal metritis (PM) and serum metabolites, uterine health,milk yield, and reproductive performance in dairy cows. Blood samples from 150 Holstein dairy cows were collectedjust after calving, and at 1, 2, and 4 weeks postpartum to measure serum concentrations of β-hydroxybutyrate (BHBA),urea nitrogen, total cholesterol (TCH), albumin, aspartate aminotransferase (AST), calcium, and magnesium. PM wasdiagnosed by the presence of fever (≥ 39.5oC) and a watery, fetid uterine discharge during the first 14 days after calving. Cows were divided into two groups on the basis of the presence or absence of the disease: a control group (n = 83)and a PM group (n = 67). The cows diagnosed with PM were subcutaneously administered with 2.2 mg/kg ceftiofurfor 3-5 days. The serum concentrations of BHBA tended to be higher (P = 0.06) and AST was higher (P < 0.05) inthe PM group than in the control group 1 week after calving, whereas serum concentrations of urea nitrogen, TCH,albumin, calcium, and magnesium were lower (P < 0.05-0.0001) after calving in the PM group than in the controlgroup. The probability of clinical endometritis was higher (odds ratio = 5.40, P < 0.001) in the PM group than in thecontrol group. Moreover, the proportion of neutrophils in the uterus was also higher in the PM group than in thecontrol group 4, 6, and 8 weeks after calving (P < 0.001). The mean milk yield 1 and 2 months after calving waslower (P = 0.05) in the PM group than in the control group. The hazard of pregnancy by 180 days after calving tendedto be lower (hazard ratio = 0.60, P = 0.07) in the PM group than in the control group, which led to an extended meaninterval between calving and pregnancy (19 days) in the PM group (P < 0.01). In conclusion, PM is associated withhigher postpartum concentrations of BHBA and AST, and lower concentrations of urea nitrogen, TCH, albumin, calcium,and magnesium. Moreover, PM is associated with subsequent poor uterine health, lower milk yield, and poorerreproductive performance in dairy cows.
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KEYWORD
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puerperal metritis, metabolite, uterine health, milk yield, reproduction, dairy cow
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